Uveal melanoma: From diagnosis to treatment and the science in between

Chandrani Chattopadhyay, Dae Won Kim, Dan S. Gombos, Junna Oba, Yong Qin, Michelle D. Williams, Bita Esmaeli, Elizabeth A. Grimm, Jennifer A. Wargo, Scott E. Woodman, Sapna P. Patel

研究成果: Review article査読

167 被引用数 (Scopus)

抄録

Melanomas of the choroid, ciliary body, and iris of the eye are collectively known as uveal melanomas. These cancers represent 5% of all melanoma diagnoses in the United States, and their age-adjusted risk is 5 per 1 million population. These less frequent melanomas are dissimilar to their more common cutaneous melanoma relative, with differing risk factors, primary treatment, anatomic spread, molecular changes, and responses to systemic therapy. Once uveal melanoma becomes metastatic, therapy options are limited and are often extrapolated from cutaneous melanoma therapies despite the routine exclusion of patients with uveal melanoma from clinical trials. Clinical trials directed at uveal melanoma have been completed or are in progress, and data from these well designed investigations will help guide future directions in this orphan disease.

本文言語English
ページ(範囲)2299-2312
ページ数14
ジャーナルCancer
122
15
DOI
出版ステータスPublished - 2016 3月 15
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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