Variation in the correlation of G + C composition with synonymous codon usage bias among bacteria

Haruo Suzuki, Rintaro Saito, Masaru Tomita

研究成果: Article査読

5 被引用数 (Scopus)

抄録

G + C composition at the third codon position (GC3) is widely reported to be correlated with synonymous codon usage bias. However, no quantitative attempt has been made to compare the extent of this correlation among different genomes. Here, we applied Shannon entropy from information theory to measure the degree of GC3 bias and that of synonymous codon usage bias of each gene. The strength of the correlation of GC3 with synonymous codon usage bias, quantified by a correlation coefficient, varied widely among bacterial genomes, ranging from -0.07 to 0.95. Previous analyses suggesting that the relationship between GC3 and synonymous codon usage bias is independent of species are thus inconsistent with the more detailed analyses obtained here for individual species.

本文言語English
論文番号61374
ジャーナルEurasip Journal on Bioinformatics and Systems Biology
2007
DOI
出版ステータスPublished - 2007

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Computer Science Applications
  • Computational Mathematics

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