TY - JOUR
T1 - Various facets of vertebrate cilia
T2 - Motility, signaling, and role in adult neurogenesis
AU - Huang, Shihhui
AU - Hirota, Yuki
AU - Sawamoto, Kazunobu
PY - 2009/10
Y1 - 2009/10
N2 - Cilia are microtubule-based cellular organelles that are widely distributed in vertebrate tissues. They were first observed hundreds of years ago. Recent studies indicate that this small organelle plays important roles in numerous physiological phenomena, including tissue morphogenesis, signal transduction, determination of left-right asymmetry during development, and adult neurogenesis. Ciliopathies, syndromes resulting from a genetic disorder of cilial components, frequently have complex effects involving many organ systems, owing to the broad distribution of cilia in the body.
AB - Cilia are microtubule-based cellular organelles that are widely distributed in vertebrate tissues. They were first observed hundreds of years ago. Recent studies indicate that this small organelle plays important roles in numerous physiological phenomena, including tissue morphogenesis, signal transduction, determination of left-right asymmetry during development, and adult neurogenesis. Ciliopathies, syndromes resulting from a genetic disorder of cilial components, frequently have complex effects involving many organ systems, owing to the broad distribution of cilia in the body.
KW - Cilia
KW - Ciliopathy
KW - Morphogenesis
UR - http://www.scopus.com/inward/record.url?scp=74949092032&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74949092032&partnerID=8YFLogxK
U2 - 10.2183/pjab.85.324
DO - 10.2183/pjab.85.324
M3 - Review article
C2 - 19838012
AN - SCOPUS:74949092032
VL - 85
SP - 324
EP - 336
JO - Proceedings of the Japan Academy Series B: Physical and Biological Sciences
JF - Proceedings of the Japan Academy Series B: Physical and Biological Sciences
SN - 0386-2208
IS - 8
ER -