Vascular endothelial growth factor suppresses C-type natriuretic peptide secretion

Kentaro Doi, Hiroshi Itoh, Yasato Komatsu, Toshio Igaki, Tae Hwa Chun, Kazuhiko Takaya, Jun Yamashita, Mayumi Inoue, Takaaki Yoshimasa, Kazuwa Nakao

研究成果: Article査読

44 被引用数 (Scopus)

抄録

Angiogenesis plays a pivotal role not only in wound healing and tumor progression but also in diabetic angiopathy, arteriosclerosis, and collateral formation of obstructive vascular diseases. Vascular endothelial growth factor (VEGF) is now thought to be an endothelium-specific and potent angiogenic factor. We previously demonstrated that C-type natriuretic peptide (CNP), originally isolated from porcine brain, is produced by endothelial cells and proposed that CNP can exert control over vascular tone and growth as a local vascular regulator. In the present study, we examined the effect of VEGF on CNP secretion from endothelial cells using the specific radioimmunoassay for CNP we developed. VEGF (1 to 100 ng/mL) dose-dependently suppressed CNP secretion from cultured bovine endothelial cells, and 100 ng/mL VEGF suppressed endothelial CNP secretion to 28% of control levels (31.7 ± 5.5 versus 8.9 ± 0.8 fmol/mL, vehicle versus VEGF). VEGF also suppressed CNP mRNA expression in endothelial cells 9 hours after administration. In contrast, basic fibroblast growth factor (20 ng/mL), an endothelium-nonspecific angiogenic factor, significantly stimulated CNP secretion by 290%. These results indicate that VEGF can regulate vascular tone and growth in the process of angiogenesis through suppression of endothelial secretion of CNP, which is an endothelium-derived vasorelaxing and growth-inhibitory peptide.

本文言語English
ページ(範囲)811-815
ページ数5
ジャーナルHypertension
27
3 II
DOI
出版ステータスPublished - 1996 3月
外部発表はい

ASJC Scopus subject areas

  • 内科学

フィンガープリント

「Vascular endothelial growth factor suppresses C-type natriuretic peptide secretion」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル