@article{2df39b8220d04581a19280b473b54feb,
title = "Vascular stress response and endothelial vasoactive factors for vascular remodelling",
abstract = "In response to several vascular stresses caused by hyperglycaemia, hypertension or hyperlipidemia, endothelial cells (EC) sense these stresses as oxidative stress to secrete several autocrine/paracrine factors, including growth factors/cytokines and vasoactive peptides to regulate vascular tone and remodelling. Vascular stresses induce co-ordinate gene regulation of endothelial vasoactive substances and their related enzymes to cause vasorelaxation and vascular growth inhibition. We speculate that prolonged and excessive vascular stresses impair endothelial function, which results in the imbalance of endothelial production of vasoactive substances and leads to the formation of proliferative vascular lesions.",
keywords = "Endothelial cells, Oxidative stress, Shear stress, Vasoactive substances",
author = "Hiroshi Itoh and Kazuwa Nakao",
note = "Funding Information: This work was supported in part by research grants from the Japanese Ministry of Education, Science and Culture; Japanese Ministry of Health and Welfare {\textquoteleft}Disorders of Adrenal Hormone{\textquoteright} Research Committee, Japan; {\textquoteleft}Molecular Approach for the Pathogenesis of Immunological Disorder{\textquoteright} Research Committee; Japanese Society for the Promotion of Science {\textquoteleft}Research for the Future{\textquoteright} program (JSPS-RFTF 96100204; JSPS-RFTF 98L00801); Smoking Research Foundation; Yamanouchi Foundation for Research on Metabolic Disorders. We would also like to thank A. Sone, H. Kitoh and Y. Takada for their excellent secretarial work.",
year = "1999",
month = sep,
doi = "10.1016/S0168-8227(99)00035-2",
language = "English",
volume = "45",
pages = "83--88",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",
number = "2-3",
}