Vascular stress response and endothelial vasoactive factors for vascular remodelling

Hiroshi Itoh, Kazuwa Nakao

研究成果: Article査読

10 被引用数 (Scopus)

抄録

In response to several vascular stresses caused by hyperglycaemia, hypertension or hyperlipidemia, endothelial cells (EC) sense these stresses as oxidative stress to secrete several autocrine/paracrine factors, including growth factors/cytokines and vasoactive peptides to regulate vascular tone and remodelling. Vascular stresses induce co-ordinate gene regulation of endothelial vasoactive substances and their related enzymes to cause vasorelaxation and vascular growth inhibition. We speculate that prolonged and excessive vascular stresses impair endothelial function, which results in the imbalance of endothelial production of vasoactive substances and leads to the formation of proliferative vascular lesions.

本文言語English
ページ(範囲)83-88
ページ数6
ジャーナルDiabetes Research and Clinical Practice
45
2-3
DOI
出版ステータスPublished - 1999 9月
外部発表はい

ASJC Scopus subject areas

  • 内科学
  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

フィンガープリント

「Vascular stress response and endothelial vasoactive factors for vascular remodelling」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル