Vasorelaxation induced by pulsed ultraviolet light irradiation in vivo: involvement of photochemical nitric oxide and photoacoustic wave effect

Yuji M.D. Morimoto, Hirotaka M.D. Matsuo, Tsunenori M.D. Arai, Makoto Kikuchi

研究成果: Conference contribution

抜粋

We examined a participation of photochemical nitric oxide in the vasorelaxation induced by ultraviolet pulsed light. We measured a luminal diameter of rat femoral artery in vivo during a Krypton-fluoride (KrF) excimer laser irradiation. We also measured the vascular response when the artery was pretreated with sodium nitrite, superoxide dismutase or methylene blue. Histological changes in the vessels were examined by light microscopy. The vessel relaxed by KrF laser. The vasorelaxation was dependent on the repetition rate under the constant total energy. On the contrary, the vessel wall damage was inversely proportional to the repetition rate. Accordingly, the damage is most likely due to photoacoustic mechanism. The vasorelaxation was inhibited by methylene blue but enhanced by sodium nitrite or superoxide dismutase, which strongly suggests that the relaxation is closely related to nitric oxide. We conclude that the photochemical product of nitric oxide may be one of the possible mechanisms for the pulsed ultraviolet light induced vasorelaxation.

元の言語English
ホスト出版物のタイトルProceedings of SPIE - The International Society for Optical Engineering
出版者Society of Photo-Optical Instrumentation Engineers
ページ298-301
ページ数4
ISBN(印刷物)0819423866
出版物ステータスPublished - 1997 12 1
イベントLaser-Tissue Interaction VIII - San Jose, CA, USA
継続期間: 1997 2 91997 2 12

出版物シリーズ

名前Proceedings of SPIE - The International Society for Optical Engineering
2975
ISSN(印刷物)0277-786X

Other

OtherLaser-Tissue Interaction VIII
San Jose, CA, USA
期間97/2/997/2/12

    フィンガープリント

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

これを引用

Morimoto, Y. M. D., Matsuo, H. M. D., Arai, T. M. D., & Kikuchi, M. (1997). Vasorelaxation induced by pulsed ultraviolet light irradiation in vivo: involvement of photochemical nitric oxide and photoacoustic wave effect. : Proceedings of SPIE - The International Society for Optical Engineering (pp. 298-301). (Proceedings of SPIE - The International Society for Optical Engineering; 巻数 2975). Society of Photo-Optical Instrumentation Engineers.