Ventilation-perfusion inequality and diffusion impairment in acutely injured lungs

Kazuhiro Yamaguchi, Masaaki Mori, Akira Kawai, Tomoaki Takasugi, Kochiro Asano, Yoshitaka Oyamada, Takuya Aoki, Hirofumi Fujita, Yukio Suzuki, Fumihiro Yamasawa, Takeo Kawashiro

研究成果: Article

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To assess the significant role of diffusion impairment and its unequal distribution in acutely injured lungs with alveolar flooding, oleic acid was intravenously injected into twenty-five mongrel dogs. The animals were divided into two groups, A and B. 0.1% CO in air was delivered, as an inspired gas, to the animals of group A. Simultaneously, saline containing a trace amount of six foreign inert gases was infused through a peripheral vein. While allowing the animals in group B to breathe air, saline containing ethylene, acetylene and freon 22 was infused. After injection of oleic acid, group A revealed increase in intrapulmonary shunt accompanied by a marked broadening of ventilation-perfusion ( V ̇A Q ̇) and diffusing capacity-perfusion ( G Q ̇) distributions. A considerable amount of total cardiac output was received by the lung areas with low G Q ̇ ratios where significant diffusion limitation was predicted to occur. Group B showed that excretion of freon 22 (gas with lower diffusivity) in injured lungs was considerably distorted as compared to those of ethylene and acetylene (gases with higher diffusivities), again ascertaining the importance of diffusion limitation in lungs with exudate in alveolar regions.

元の言語English
ページ(範囲)165-177
ページ数13
ジャーナルRespiration Physiology
98
発行部数2
DOI
出版物ステータスPublished - 1994 10

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

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    Yamaguchi, K., Mori, M., Kawai, A., Takasugi, T., Asano, K., Oyamada, Y., Aoki, T., Fujita, H., Suzuki, Y., Yamasawa, F., & Kawashiro, T. (1994). Ventilation-perfusion inequality and diffusion impairment in acutely injured lungs. Respiration Physiology, 98(2), 165-177. https://doi.org/10.1016/0034-5687(94)00061-1