抄録
Verrucarin A is an inhibitor of protein synthesis. In this study, we examined the inhibitory action of verrucarin A on signal molecules. Verrucarin A partially inhibited the IL-8 production of a PMA-stimulated promyelocytic leukemia cell line (HL-60 cells), and the effect was related to the inhibition of NF-κB activation at non-cytotoxic concentrations. Moreover, the inhibition of mitogen activated protein (MAP) kinase by verrucarin A was especially strong with p38- and JNK-phosphorylation. The findings show a new action of verrucarin A, and it is expected that this action relaxes the signal activation in response to stress.
本文言語 | English |
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ページ(範囲) | 64-73 |
ページ数 | 10 |
ジャーナル | Marine Drugs |
巻 | 3 |
号 | 2 |
DOI | |
出版ステータス | Published - 2005 6月 2 |
外部発表 | はい |
ASJC Scopus subject areas
- 創薬