Verrucarin A inhibition of MAP kinase activation in a PMA-stimulated promyelocytic leukemia cell line

Taiko Oda, Michio Namikoshi, Kyoko Akano, Hisayoshi Kobayashi, Yoshio Honma, Tadashi Kasahara

研究成果: Article査読

23 被引用数 (Scopus)

抄録

Verrucarin A is an inhibitor of protein synthesis. In this study, we examined the inhibitory action of verrucarin A on signal molecules. Verrucarin A partially inhibited the IL-8 production of a PMA-stimulated promyelocytic leukemia cell line (HL-60 cells), and the effect was related to the inhibition of NF-κB activation at non-cytotoxic concentrations. Moreover, the inhibition of mitogen activated protein (MAP) kinase by verrucarin A was especially strong with p38- and JNK-phosphorylation. The findings show a new action of verrucarin A, and it is expected that this action relaxes the signal activation in response to stress.

本文言語English
ページ(範囲)64-73
ページ数10
ジャーナルMarine Drugs
3
2
DOI
出版ステータスPublished - 2005 6 2

ASJC Scopus subject areas

  • 創薬

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