@article{971343f4601d4863a60f6740736269fd,
title = "Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice",
abstract = "Myopia has become a major public health concern, particularly across much of Asia. It has been shown in multiple studies that outdoor activity has a protective effect on myopia. Recent reports have shown that short-wavelength visible violet light is the component of sunlight that appears to play an important role in preventing myopia progression in mice, chicks, and humans. The mechanism underlying this effect has not been understood. Here, we show that violet light prevents lens defocus-induced myopia in mice. This violet light effect was dependent on both time of day and retinal expression of the violet light sensitive atypical opsin, neuropsin (OPN5). These findings identify Opn5-expressing retinal ganglion cells as crucial for emmetropization in mice and suggest a strategy for myopia prevention in humans.",
keywords = "Myopia, Neuropsin (OPN5), Nonvisual photoreceptors, Violet light",
author = "Xiaoyan Jiang and Pardue, {MacHelle T.} and Kiwako Mori and Ikeda, {Shin Ichi} and Hidemasa Torii and Shane D'Souza and Lang, {Richard A.} and Toshihide Kurihara and Kazuo Tsubota",
note = "Funding Information: ACKNOWLEDGMENTS. This work was supported by Grants-in-Aid for Scientific Research (KAKENHI, Grant 18K09424) from the Ministry of Education, Culture, Sports, Science and Technology to T.K. This work is also supported by the Grant for Myopia Research from Tsubota Laboratory, Inc. (Tokyo, Japan), National Eye Institute, NIH (Grant EY016435 to M.T.P.), and Senior Research Career Scientist Award from Rehab R&D Service, Department of Veterans Affairs (Grant IK6 RX003134 to M.T.P.). Publisher Copyright: {\textcopyright} 2021 National Academy of Sciences. All rights reserved.",
year = "2021",
month = jun,
day = "1",
doi = "10.1073/pnas.2018840118",
language = "English",
volume = "118",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "22",
}