Vitamin B1 Supports the Differentiation of T Cells through TGF-β Superfamily Production in Thymic Stromal Cells

So ichiro Hirata, Kento Sawane, Jun Adachi, Junko Isoyama, Yuki Sugiura, Ayu Matsunaga, Koji Hosomi, Takeshi Tomonaga, Makoto Suematsu, Takahiro Nagatake, Jun Kunisawa

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Homeostatic generation of T cells, which occurs in the thymus, is controlled at least in part by endogenous cytokines and ligands. In addition, nutritional factors are other key regulators for the homeostasis of host immunity, but whether and how nutrition affects the homeostatic generation of thymocytes remains to be established. Here, we showed that vitamin B1 deficiency resulted in a bias toward the maturation of γδ thymocytes accompanied by decreased differentiation into double-positive thymocytes during thymic involution. These events were mediated through the increased production of TGF-β superfamily members due to the accumulation of branched-chain α-keto acids in thymic stromal cells. These findings revealed essential roles of vitamin B1 in the appropriate differentiation of T cells through the metabolism of thymic stromal cells.

本文言語English
論文番号101426
ジャーナルiScience
23
9
DOI
出版ステータスPublished - 2020 9 25

ASJC Scopus subject areas

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