Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes

Yoshiko Motohashi, Satoru Yamada, Tatsuo Yanagawa, Taro Maruyama, Ryuji Suzuki, Masaaki Niino, Toshiyuki Fukazawa, Akira Kasuga, Hiroshi Hirose, Koichi Matsubara, Akira Shimada, Takao Saruta

研究成果: Article査読

84 被引用数 (Scopus)

抄録

Type 1 diabetes mellitus is recognized as a T-cell-mediated autoimmune disease. Vitamin D compounds are known to suppress T-cell activation by binding to the vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases. We, therefore, investigated a VDR gene polymorphism in type 1 diabetes. We examined the VDR gene Bsm I polymorphism in 203 type 1 diabetic patients and 222 controls, and the association between the VDR gene polymorphism and type 1 diabetes and their onset pattern. We found a significantly higher frequency of B allele in type 1 diabetics overall, compared with controls (P = 0.0010). Moreover, there was a significant difference in B-allele frequency between acute-onset type 1 diabetics and controls (P = 0.0002), whereas this difference was not observed between slow-onset type 1 diabetics and controls. Regardless of the existence of islet-associated autoantibody, we found a significant difference in B-allele frequency between acute-onset type 1 diabetics and controls. In conclusion, we found an association between a VDR gene polymorphism and acute-onset type 1 diabetes. Assessment of this VDR gene polymorphism may contribute to prediction of the onset pattern in individuals with a high risk of type 1 diabetes.

本文言語English
ページ(範囲)3137-3140
ページ数4
ジャーナルJournal of Clinical Endocrinology and Metabolism
88
7
DOI
出版ステータスPublished - 2003 7 1

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 生化学
  • 内分泌学
  • 臨床生化学
  • 生化学、医学

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