TY - JOUR
T1 - Vitamin K2 improves femoral bone strength without altering bone mineral density in gastrectomized rats
AU - Iwamoto, Jun
AU - Sato, Yoshihiro
AU - Matsumoto, Hideo
PY - 2014
Y1 - 2014
N2 - Gastrectomy (GX) induces osteopenia in rats. The present study examined the skeletal effects of vitamin K2 in GX rats. Thirty male Sprague-Dawley rats (12 wk old) were randomized by the stratifed weight method into the following three groups of 10 animals each: sham operation (control) group; GX group; and GX1oral vitamin K2 (menatetre-none, 30 mg/kg, 5 d/wk) group. Treatment was initiated at 1 wk after surgery. After 6 wk of treatment, the bone mineral content (BMC), bone mineral density (BMD), and mechanical strength of the femoral diaphysis and distal metaphysis were determined by peripheral quantitative computed tomography and mechanical strength tests, respectively. GX induced decreases in the BMC, BMD, and ultimate force of the femoral diaphysis and distal metaphy-sis. Vitamin K2 did not signifcantly infuence the BMC or BMD of the femoral diaphysis or distal metaphysis in GX rats, but attenuated the decrease in the ultimate force and increased the stiffness of the femoral diaphysis. The present study showed that administration of vitamin K2 to GX rats improved the bone strength of the femoral diaphysis without altering the BMC or BMD, suggesting effects of vitamin K2 on the cortical bone quality.
AB - Gastrectomy (GX) induces osteopenia in rats. The present study examined the skeletal effects of vitamin K2 in GX rats. Thirty male Sprague-Dawley rats (12 wk old) were randomized by the stratifed weight method into the following three groups of 10 animals each: sham operation (control) group; GX group; and GX1oral vitamin K2 (menatetre-none, 30 mg/kg, 5 d/wk) group. Treatment was initiated at 1 wk after surgery. After 6 wk of treatment, the bone mineral content (BMC), bone mineral density (BMD), and mechanical strength of the femoral diaphysis and distal metaphysis were determined by peripheral quantitative computed tomography and mechanical strength tests, respectively. GX induced decreases in the BMC, BMD, and ultimate force of the femoral diaphysis and distal metaphy-sis. Vitamin K2 did not signifcantly infuence the BMC or BMD of the femoral diaphysis or distal metaphysis in GX rats, but attenuated the decrease in the ultimate force and increased the stiffness of the femoral diaphysis. The present study showed that administration of vitamin K2 to GX rats improved the bone strength of the femoral diaphysis without altering the BMC or BMD, suggesting effects of vitamin K2 on the cortical bone quality.
KW - Bone mineral density
KW - Bone strength
KW - Cortical bone
KW - Gastrectomy
KW - Vitamin K
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U2 - 10.3177/jnsv.60.71
DO - 10.3177/jnsv.60.71
M3 - Article
C2 - 24975215
AN - SCOPUS:84903614133
VL - 60
SP - 71
EP - 77
JO - The Journal of vitaminology
JF - The Journal of vitaminology
SN - 0301-4800
IS - 2
ER -