WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis

Tetsuro Morisaki, Toru Hirota, Shin ichi Iida, Tomotoshi Marumoto, Toshihiro Hara, Yasuyuki Nishiyama, Michio Kawasuzi, Takehisa Hiraoka, Tatsuyuki Mimori, Norie Araki, Ichiro Izawa, Masaki Inagaki, Hideyuki Saya

研究成果: Article査読

37 被引用数 (Scopus)

抄録

Identification of physiological substrates for Cdc2/cyclin B is crucial for understanding the functional link between mitotic events and Cdc2/cyclin B activation. A human homologue of the Drosophila warts tumor suppressor, termed WARTS, is a serine/threonine kinase and a dynamic component of the mitotic apparatus. We have found that Cdc2/cyclin B forms a complex with a fraction of WARTS in the centrosome and phosphorylates the Ser613 site of WARTS during mitosis. Immunocytochemical analysis has shown that the S613-phosphorylated WARTS appears in the spindle poles at prometaphase and disappears at telophase. Our findings suggest that Cdc/cyclin B regulates functions of WARTS on the mitotic apparatus.

本文言語English
ページ(範囲)319-324
ページ数6
ジャーナルFEBS Letters
529
2-3
DOI
出版ステータスPublished - 2002 10 9
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

フィンガープリント

「WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル