Water permeable nanoporous membrane for implantable hemodialysis device

This paper experimentally characterized water permeable nanoporous membranes for hemodialysis applications both in vitro and in vivo. We developed water-permeable and robust nanoporous membrane from a casting solution of polyether sulfone (PES), polyethylene glycol (PEG), and Dimethylacetamide (DMAc). In vitro tests verified that the membrane had higher water permeability than prior work and did not cause any leakage. Then, a hemodialysis device equipped with the developed membranes were connected to rat artery and vein and its permeability characteristics were evaluated. Aqueous filtrate was successfully collected, whose amount was affected by the blood pressure.