Water-soluble fullerene derivatives for drug discovery

Shigeo Nakamura, Tadahiko Mashino

研究成果: Review article査読

31 被引用数 (Scopus)

抄録

Fullerenes (represented by buckminsterfullerene, C60) are a new kind of organic compound with a cage-like structure. A great deal of attention has been focused on their unique properties. From the viewpoint of drug discovery, fullerenes could be novel lead compounds for drug discovery. However, fullerenes are poorly soluble in aqueous media. Incorporation of water-soluble groups into the fullerene core enables investigation of its biological activities. Certain fullerene derivatives show inhibitory activity against human immunodeficiency virus reverse transcriptase. Hepatitis C virus RNA polymerase is also inhibited by fullerene derivatives. Therefore, fullerene derivatives are candidate antiviral agents. In addition, fullerene derivatives exhibit antiproliferative activity by inducing apoptosis related to the generation of reactive oxygen species. Fullerene derivatives also have the potential to be anticancer drugs.

本文言語English
ページ(範囲)248-254
ページ数7
ジャーナルJournal of Nippon Medical School
79
4
DOI
出版ステータスPublished - 2012 8

ASJC Scopus subject areas

  • 医学(全般)

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