Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for eiger signaling

Hiroshi Kanda, Tatsushi Igaki, Hirotaka Kanuka, Takeshi Yagi, Masayuki Miura

研究成果: Article査読

137 被引用数 (Scopus)

抄録

We identified Wengen, the first member of the Drosophila tumor necrosis factor receptor (TNFR) superfamily. Wengen is a type III membrane protein with conserved cysteine-rich residues (TNFR homology domain) in the extracellular domain, a hallmark of the TNFR superfamily. wengen mRNA is expressed at all stages of Drosophila development. The small-eye phenotype caused by an eye-specific overexpression of a Drosophila TNF superfamily ligand, Eiger, was dramatically suppressed by down-regulation of Wengen using RNA interference. In addition, Wengen and Eiger physically interacted with each other through their TNFR homology domain and TNF homology domain, respectively. These results suggest that Wengen can act as a component of a functional receptor for Eiger. Our identification of Wengen and further genetic analysis should provide increased understanding of the evolutionarily conserved roles of TNF/TNFR superfamily proteins in normal development, as well as in some pathophysiological conditions.

本文言語English
ページ(範囲)28372-28375
ページ数4
ジャーナルJournal of Biological Chemistry
277
32
DOI
出版ステータスPublished - 2002 8 9

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 細胞生物学

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