What Can Stem Cell Models Tell Us About Human Germ Cell Biology?

Naoko Irie, Anastasiya Sybirna, M. Azim Surani

研究成果: Chapter

10 被引用数 (Scopus)

抄録

Fusion of sperm and egg generates a totipotent zygote that develops into a whole organism. Accordingly, the “immortal” germline transmits genetic and epigenetic information to subsequent generations with consequences for human health and disease. In mammals, primordial germ cells (PGCs) originate from peri-gastrulation embryos. While early human embryos are inaccessible for research, in vitro model systems using pluripotent stem cells have provided critical insights into human PGC specification, which differs from that in mice. This might stem from significant differences in early embryogenesis at the morphological and molecular levels, including pluripotency networks. Here, we discuss recent advances and experimental systems used to study mammalian germ cell development. We also highlight key aspects of germ cell disorders, as well as mitochondrial and potentially epigenetic inheritance in humans.

本文言語English
ホスト出版物のタイトルCurrent Topics in Developmental Biology
編集者Ali H. Brivanlou
出版社Academic Press Inc.
ページ25-65
ページ数41
ISBN(印刷版)9780128042519
DOI
出版ステータスPublished - 2018 1月 1
外部発表はい

出版物シリーズ

名前Current Topics in Developmental Biology
129
ISSN(印刷版)0070-2153

ASJC Scopus subject areas

  • 発生生物学
  • 細胞生物学

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