White matter aberrations in prepubertal estrogen-naive girls with monosomic turner syndrome

Bun Yamagata, Naama Barnea-Goraly, Matthew J. Marzelli, Yaena Park, David S. Hong, Masaru Mimura, Allan L. Reiss

研究成果: Article

22 引用 (Scopus)

抜粋

Turner syndrome (TS) offers a unique opportunity to investigate associations among genes, the brain, and cognitive phenotypes. In this study, we used 3 complementary analyses of diffusion tensor imaging (DTI) data (whole brain, region of interest, and fiber tractography) and a whole brain volumetric imaging technique to investigate white matter (WM) structure in prepubertal, nonmosaic, estrogen-naive girls with TS compared with age and sex matched typically developing controls. The TS group demonstrated significant WM aberrations in brain regions implicated in visuospatial abilities, face processing, and sensorimotor and social abilities compared with controls. Extensive spatial overlap between regions of aberrant WM structure (from DTI) and regions of aberrant WM volume were observed in TS. Our findings indicate that complete absence of an X chromosome in young females (prior to receiving exogenous estrogen) is associated with WM aberrations in specific regions implicated in characteristic cognitive features of TS.

元の言語English
ページ(範囲)2761-2768
ページ数8
ジャーナルCerebral Cortex
22
発行部数12
DOI
出版物ステータスPublished - 2012 12 1
外部発表Yes

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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