White matter structures associated with loneliness in young adults

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

研究成果: Article査読

42 被引用数 (Scopus)

抄録

Lonely individuals may exhibit dysfunction, particularly with respect to social empathy and self-efficacy. White matter (WM) structures related to loneliness have not yet been identified. We investigated the association between regional WM density (rWMD) using the UCLA Loneliness Scale in 776 healthy young students aged 18-27 years old. Loneliness scores were negatively correlated with rWMD in eight clusters: the bilateral inferior parietal lobule (IPL), right anterior insula (AI), posterior temporoparietal junction (pTPJ), left posterior superior temporal sulcus (pSTS), dorsomedial prefrontal cortex (dmPFC), and rostrolateral prefrontal cortex (RLPFC). The bilateral IPL, right AI, left pSTS, pTPJ, and RLPFC were strongly associated with Empathy Quotient (EQ), whereas the bilateral IPL, right AI, left pTPJ, and dmPFC were associated with General Self-Efficacy Scale (GSES) score. The neural correlates of loneliness comprise widespread reduction in WMD in areas related to self-and social cognition as well as areas associated with empathy and self-efficacy.

本文言語English
論文番号17001
ジャーナルScientific reports
5
DOI
出版ステータスPublished - 2015 11月 20
外部発表はい

ASJC Scopus subject areas

  • 一般

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