Widely applicable deprotection method of 2,2,2-trichloroethoxycarbonyl (Troc) group using tetrabutylammonium fluoride

Cheng Yuan Huang, Ning Wang, Katsumasa Fujiki, Yuji Otsuka, Masao Akamatsu, Yukari Fujimoto, Koichi Fukase

研究成果: Article査読

17 被引用数 (Scopus)

抄録

The N-Troc (2,2,2-trichloroethoxycarbonyl) groups in glucosamine and muramic acid derivatives were removed by treatment with tetrabutylammonium fluoride (TBAF) under mild conditions. The use of Troc protection for the amino group in aminosugars such as glucosamine is increasing the importance for selective and efficient glycosylation, and the cleavage method described here will expand the available opportunities for using the Troc group in the preparation of a variety of glycans. This cleavage is especially advantageous for compounds that are labile or may be decomposed under acidic conditions, strong basic conditions, or reductive conditions.

本文言語English
ページ(範囲)289-298
ページ数10
ジャーナルJournal of Carbohydrate Chemistry
29
6
DOI
出版ステータスPublished - 2010 8
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 有機化学

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