Wnt Signaling in the Niche

Toshio Suda, Fumio Arai

研究成果: Short survey査読

37 被引用数 (Scopus)

抄録

There is much interest in understanding the signals in the bone marrow niche that keep hematopoietic stem cells (HSCs) in a quiescent state. In the current issue of Cell Stem Cell, Fleming et al. (2008) report that blocking Wnt signaling in the niche increases the number of proliferating HSCs and reduces their ability to reconstitute the hematopoietic system of irradiated recipient mice. These findings show that Wnt/β-catenin activity is crucial for the maintenance of HSC quiescence in the bone marrow niche.

本文言語English
ページ(範囲)729-730
ページ数2
ジャーナルCell
132
5
DOI
出版ステータスPublished - 2008 3 7

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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