Wound-associated skin fibrosis: mechanisms and treatments based on modulating the inflammatory response.

Tanya J. Shaw, Kazuo Kishi, Ryoichi Mori

研究成果: Review article

28 引用 (Scopus)

抜粋

Skin fibrosis, in its mildest form, may present only a minor aesthetic problem, but in the most severe cases it can lead to debilitating pathologies of the skin, for example keloid and hypertrophic scars, and systemic sclerosis. In recent years, extensive basic research aimed at understanding the molecular mechanisms underlying fibrosis has revealed an impressive but baffling number of genes, molecules, and cell types that may contribute to this problem. However, one recurring and consistent theme in these studies is that inflammatory cells and their secreted mediators appear to be leading culprits in activating dermal fibroblasts to become fibrotic. This review will first describe the histology of normal versus fibrotic skin, and will also describe the process of wound repair, a primary cause of skin fibrosis. We will then focus on what is currently known about the molecular mechanisms underlying skin fibrosis, with particular attention paid to how inflammation contributes. Finally, current treatment strategies and emerging therapeutic targets will be discussed.

元の言語English
ページ(範囲)320-330
ページ数11
ジャーナルEndocrine, metabolic & immune disorders drug targets
10
発行部数4
出版物ステータスPublished - 2010 12 1
外部発表Yes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy

フィンガープリント Wound-associated skin fibrosis: mechanisms and treatments based on modulating the inflammatory response.' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用