Xylogranin B: A potent Wnt signal inhibitory limonoid from Xylocarpus granatum

Kazufumi Toume, Kentaro Kamiya, Midori A. Arai, Naomi Mori, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi

研究成果: Article査読

27 被引用数 (Scopus)

抄録

Xylogranin B (2) was isolated from Xylocarpus granatum (Meliaceae) leaves, by use of a cell-based luciferase screening system targeting a Wnt signaling pathway. Compound 2 inhibited TCF/β-catenin transcriptional activity (IC50 48.9 nM) and exhibited strong cytotoxicity against colon cancer cell lines. Compound 2 significantly decreased β-catenin protein levels in nuclei but not in the cytosol. These results indicated that a decrease in β-catenin levels in nuclei by 2 resulted in the Wnt signal inhibitory effects of 2.

本文言語English
ページ(範囲)6106-6109
ページ数4
ジャーナルOrganic Letters
15
23
DOI
出版ステータスPublished - 2013 12 6
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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