Yeast-mediated synthesis of optically active diols with C2-symmetry and (R)-4-pentanolide

Hajime Ikeda, Eriko Sato, Takeshi Sugai, Hiromichi Ohta

研究成果: Article査読

48 被引用数 (Scopus)

抄録

Reduction of some diketones and a ketoacid with yeast, Pichia farinosa IAM 4682 was examined. The reduction of carbonyl groups proceeded highly selectively with an anti-Prelog fashion to give (R)-alcohols. (2R,5R)-2,5-Hexanediol (83% yd., >99% e.e., 95% d.e.), (2R,4R)-2,4-pentanediol (94% yd., >99% e.e., 98% d.e.), and (R)-pentanolide (67% yd., >99% e.e.) were highly efficiently obtained from the corresponding ketones. Effect of the structure of substrate on the stereochemical course as well as the selectivity were discussed.

本文言語English
ページ(範囲)8113-8122
ページ数10
ジャーナルTetrahedron
52
24
DOI
出版ステータスPublished - 1996 6月 10

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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