Zonal distribution of sulfotransferase for phenol in olfactory sustentacular cells

Atsushi Miyawaki, Hiroshi Homma, Hiro Omi Tamura, Michio Matsui, Katsuhiko Mikoshiba

研究成果: Article査読

48 被引用数 (Scopus)

抄録

We have immunolocalized phenol sulfotransferase (PST)G, an isoform of PST in sustentacular cells which reside in the dorso-medial portion of the nasal cavity of the mouse. The same topographical pattern of gene expression has been reported for some olfactory neuron-specific genes. When several established (phenol-containing) odorants were used as substrate, mouse nasal tissue cytosol showed a significant level of PST activity, as does mouse liver cytosol. This study is the first to demonstrate that gene expression in the olfactory sustentacular cells is also organized zonally, and indicates the involvement of sulfo-conjugation in olfactory perireceptor processes, such as odorant clearance and xenobiotic detoxification.

本文言語English
ページ(範囲)2050-2055
ページ数6
ジャーナルEMBO Journal
15
9
DOI
出版ステータスPublished - 1996 5 1

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 生化学、遺伝学、分子生物学(全般)
  • 免疫学および微生物学(全般)

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